WHAT IS C-PEPTIDE?

Clinical studies show that C-peptide administration in type 1 diabetes patients, who lack the peptide, results in amelioration of diabetes-induced renal and nerve dysfunction.
Patients with type 1 diabetes, who continue to maintain a small endogenous beta cell activity, are less prone to develop long-term complications and have fewer episodes of hypoglycemia than those who become totally C-peptide deficient.
This particular Peptide is a part of Insulin make-up as is Amylin. Having only two parts of this composition made available in exogenous form (Insulin by way of Humalog and Novolog and Amylin by way of Symlin), we are most in need of the third which is C-Peptide.
In an article reported in Am J Physiol Endocrinol Metab 278: E759-E768, 2000;0193-1849/00, Vol. 278, Issue 5, E759-E768, May 2000
Role of C-peptide in human physiology

John Wahren1, Karin Ekberg1, Jan Johansson2, Mikael Henriksson2, Aladdin Pramanik2, Bo-Lennart Johansson1, Rudolf Rigler2, and Hans Jörnvall2
1 Department of Surgical Sciences, Section of Clinical Physiology, Karolinska Hospital, SE-171 76 Stockholm; and 2 Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden

It states that The C-peptide of proinsulin is important for the biosynthesis of insulin......"Data also indicate that C-peptide administration is accompanied by augmented blood flow in skeletal muscle and skin, diminished glomerular hyperfiltration, reduced urinary albumin excretion, and improved nerve function, all in patients with type 1 diabetes who lack C-peptide, but not in healthy subjects. The possibility exists that C-peptide replacement, together with insulin administration, may prevent the development or retard the progression of long-term complications in type 1 diabetes. Recently, new data have been presented demonstrating specific binding of C-peptide to cell surfaces in a manner that suggests the presence of G protein-coupled membrane receptors. C-peptide may thereby stimulate specific intracellular processes, influencing renal and nerve function in C-peptide-deficient type 1 diabetes patients".
"There is now evidence to indicate that replacement of C-peptide in type 1 diabetes is accompanied by improved renal function, as evidenced by correction of glomerular hyperfiltration (27, 31, 50) and diminished urinary albumin excretion (25, 27), and amelioration of nerve dysfunction (25, 26). C-peptide replacement together with insulin administration, a therapy possibly closer to nature's own way, may thus be beneficial in type 1 diabetes patients".
As all of us know(or will know) T1DM related complications are horrible and severe affecting major body organs as well as the Retina. Since C-peptide has been already shown that there is a binding to cellular receptor sites required of ATP activity(Energy) and since with the destruction of those cells that produce Insulin, there comes a destruction in the availability of Amylin and C-Peptide. The logical course would then be to provide:
1. Insulin
2. Amylin
3. C-Peptide
The first two(Insulin and Symlin are already available)
My question is why has C-peptide not been made available considering the damage that takes place to our bodies 24/7 as a result of having Diabetes. Yes, high blood sugars can cause many of these problems, but the Longevity of the Disease and its Nature is a contributing factor as well.
The research on C-Peptide is vast going back to the 1980's at least.

One of the best papers to talk about the Vital Need for the Restoration of C-Peptide in T1DM has been written and presented by Zachary T. Bloomgarden, MD, a well-known Diabetologist/Researcher here in NYC.
The article can be found in Diabetes Care 27:1506-1514, 2004 called Diabetes Complications. "C-peptide is stored with insulin in ß-cell granules, and the two are secreted in equimolecular amounts. Pancreatic or islet cell transplantation with restoration of
endogenous C-peptide leads to amelioration and, in some experimental settings, to reversal of neuropathy and nephropathy".
In addition, C-Peptide has been found to prevent/delay Retinopathy which along with Renal, Coronary, Vascular, Autonomic/Peripheral Neuropathies are very common in T1DM, more as a result of the Nature of the Disease, but of-course can be exacerbated by Hyperglycemia.

Make your feelings known to those organizations that supposedly advocate on our behalf and not theirs(although that is questionable) such as :
JDRF
American Diabetes Association
Discuss this information with your Physician and other Health-care providers. Because they wear white lab coats, does not necessarily mean that they are "up-to-date" and aware of all beneficial things related to Diabetes.
It is YOUR body.........do everything possible to give it Life.

POLYURIA AT MIDNIGHT

I could not understand it or relate my T1DM to it in any way.
For the past three nights, I had been getting up from sleep to void about 3-4X during the night.
Having Diabetes is one of those Diseases where there are so many variables and factors that tweak and influence the body 24/7.
Beginning my Sherlock Holmes investigation led me to conclude that since I had moved my exercises to the later part of the evening, that that might be the variable causing these nightly interruptions from sleep.
Even-though my bs before sleep were within normal values, I decided on the third night to do a 3:00AM reading. It was 54mg/dl. The culprit was discovered that was causing my polyuria. The late evening basal and the exercise were enough to cause the Hypoglycemia with the only symptoms being Polyuria.
We are so use to having that symptom associated with Hyperglycemia, that it is too often overlooked as being in the same category as Diaphoresis(excessive sweating) which is associated with Hypoglycemia. After-all, the loss of fluids can be accomplished through many channels besides typical sweating. These include Lung Perspiration and Polyuria.
Thank you Dr. Watson

SUBWAY MUSINGS Ⅰ

What better way when you are on a subway to get from point A to point B, then by thoughts. There are of-course other options such as, reading, sitting and starring in vacuous space, breathing in the laden germs left over from someone's cough or sneeze thrown into the closed air for all to share, listening to an iPod. The listening to an iPod which seems to be the preferable way to look these days on the subway, will eventually fall and disappear from sight as did what they replaced which carried the same passion, popularity and hipness......Sonny's Walkman.
My thoughts brought me to the feeling that there should be the availability of Insulin made FREE to all who cannot manufacture it within their bodies. That of-course would be applied to T1DM. Insulin is similar to water, without it, there would be no Life available. Too much of it, and the same Life would cease to exist. Yes, the same applies to Water. There have been a number of Deaths due to the over-consumption of Water, which caused Sodium levels to be displaced.
The Free Availability of Insulin would be made available to ALL who needed it in-order to Survive/Live regardless of Economic Standings. There would be the elimination of Red Tape and Bureaucracy which stands in the way for making things "Happen" in a timely way, so that anyone whose Life depended on Insulin(T1DM), would have it. BTW, this Red Tape and Bureaucracy is/was responsible for the horrendous problems that were uncovered at V.A. Hospitals throughout the U.S.A. in general and Walter Reade specifically.

GIVE ME A SIDE ORDER OF GLUCAGON TO GO w/THE PEANUT BUTTER SANDWICH

The morning sun enters the bedroom and plants a kiss upon my awakening body and the budding foliage within the room that awaits Spring Birth.

My exercise is done with precise movements along the bare-wood floor.

Breakfast is consumed with hot fragrant coffee that moistens my tongue and mingles with the hastily chewed potatoes and eggs.

I dress quickly to arrive for my expected appointment that never takes place. Partial snips of Matter within Time and Space greet me as if I am watching a Movie Trailer. I force myself to turn away from the strange visions before me and do a quick diagnostic which yields 37mg/dl.
Rushing to what I perceive as my Kitchen, there sits as if perched upon a twig and awaiting instructions is a can of Honey.
My palette only allows 1T as I search for other Rescuers.

An orange case flashes before me that encloses a powdery mixture with a solvent filled syringe waiting to create the Suspension that will give Life. The Glucagon is injected and the peanut butter sandwich is eaten.

LIFE ON YOUR TERMS

All of us who have a Chronic Illness or/and have experienced Near Death Phenomenon, experience a profound change in our Relationship with Life.
I have...............
Here then is a Reaffirmation for our Existence:

A CASE OF MAGAZINES

My doorbell rings with the man in Brown(UPS) holding a heavy case of "DiabetesHealth" magazine for me to sign off on. I always receive one issue/month, so this was strange that the Publisher decided to send me a case. He probably wants an increase in exposure to the magazine, so more people will subscribe to it.
So I think to myself, "What am I going to do with a whole case of this stuff". Since NYC is big and filled with many people who have the classical soma-type of Metabolic Disease, aka Insulin Resistant Disease, aka Type 2 Diabetes, that then would be the way for me to get rid of the stuff.
I am on the subways a lot and it is fairly easy to "spot" those that either have Insulin Resistant Disease or the potential/eventuality for it.
Starting off with a case of 50 magazines, I am now down to 8 copies.
My presentation, "do you or anyone in your family or friends have Diabetes"?

VALENTINE'S DAY

All of us(Men) know what this feeling is like. It is as if an Antigen has seized our bodies the way it has once before "infected us with its wrath", causing T1DM to come into existence. This time however the fever is created within the stirrings of our heart and is relentless. There is no let up, but a persistent pursuit of only that which can satisfy our longing. This is for all of us who know and who have experienced this "Thing" called Love.

DO YOU HAVE THIS ILLNESS?

CHECK-OUT AT TRADER JOE'S

Opening and ingesting small available packets of sugar found in my jacket pocket
as the Trader Joe's store clerk rings up my organic loaf bread with jars of organic creamy peanut butter......
My eyes remain open, but I continue to lose moments of consciousness while I
stand at the counter.
Groceries are bagged and given as I then tumble out the store and looked upon as "having too much to drink".
Nearest store approaches as an Angel in Rescue.
Dunkin Donuts appears as I enter the source that will be my Rescuer from the doom of impending unconsciousness.
A pornographic display of sugar coated sweetness greets me that will be the Redeemer to my20mg/dl.
I quickly order two Boston Cream Doughnuts w/Chocolate Glaze that appear in front of me like a woman's sensual breasts.
As I quickly devour them and drink down the bad tasting coffee to hasten the "fix", I slowly begin to feel my presence return back into the Time/Space Reality of Existence.

A NEW WAY TO TAKE INSULIN

One Step Closer.....Scientists/Researchers from Taiwan's National Tsing Hua University have developed a better way to administer Insulin other than injection and inhalation(not good for people w/Respiratory Problems). This would be an "Oral" administration of Insulin, similar to the taking of any pill/capsule. The problem w/oral administration of Insulin until now, is that the stomach breaks down proteins and since Insulin is a Protein, it would have been broken down before it reached the blood stream. Thus making it in-effective for oral use.
However Dr. Hsing-Wen Sung and his colleagues tricked the stomach into accepting the Insulin molecule by coating it w/Chitosan(nano particles created from the shells of shrimp, lobster, and crabs.
In testing on male rats w/Diabetes the results showed a release of the insulin into the blood stream and a lowering of blood glucose.
The next step of course would be animal and then human testing if results are favorable.
Thank you Dr. Hsing-Wen Sung and colleagues.

DO ANDROIDS DREAM OF ELECTRIC SHEEP?

In frustration with the people that work in Health Care dealing with Diabetes, I told the fairly young Certified Diabetes Educator,"you really don't know how difficult and how much time is devoted to keeping myself in a balance where everything is optimized. I have been doing this since I was 6". I then proceeded to show her as she walked with me in the street and I spread my arms horizontally to shoulder length traversing along a narrow curve in order to emphasize the difficulty in keeping a balance without falling off. My outstretched arms would go side to side as I struggled to keep the balance. She then remarked, "I have been doing that since I was 13".
It was at that point that I heard the sound of persistent meowing in the background to find myself laying on my bed as the morning sunlight entered the room and my cats tugging at me to wake up.
My blood-sugars were 50mg/dl.

(SOME) ENDOCRINOLOGISTS WHO TREAT TYPE 1 DIABETES

NEW TOOLS FOR DIABETES

It is expected in 2007 that this Diagnostic Tool(NMB- 200) for Diabetes will be able to measure Glucose in "Real Time" as well as O2 levels in the blood, red blood cells and iron in addition to the Heart Rate.... What I like best about this product, is that it is "non-invasive" and is worn like a wrist watch. No idea as to its price. Wow, who needs a doctor and lousy insurance forms with gossipy/up-tight/unprofessional office staff? Unfortunately, this probably will not be available for about one year. A reward for those who have patience. Read more:

Non-invasive Glucometry from Orsense Wins Award
Filed under: Diagnostics , Geriatrics , Medicine , Pediatrics

OrSense Ltd., of Nes Ziona, Israel, is another recipient of the technology innovation award from Frost & Sullivan for its non-invasive glucose monitoring system NBM-200. The system, based on proprietary "occlusion spectroscopy" technology, allows continuous measurement of blood glucose, hemoglobin, hematocrit, oximetry, and heart rates. Results from a clinical trial, reported in September, have shown that the system "accurately measures levels of glucose in a home-like setting."

OrSense's patented technology, known as Occlusion Spectroscopy, uses a non-invasive optical measurement platform combined with a ring-shaped cuff. The pressure applied by the cuff temporarily occludes the blood flow in the finger, creating new blood dynamics which generate a strong optical signal, yielding a high signal-to-noise ratio that is wholly blood specific. Analysis of the signal provides the sensitivity necessary to measure blood glucose, hemoglobin, and other analyte concentrations.

TAG LIST

The Music that I listen to this time of year is pretty much the same what I will listen to any other day of the year.Here is a list of the "5", which I have listened to for the past week.
1. Silent Night/The Temptations
2. The Way You Look Tonight/The Jaguars
3. Visions Of Johanna/Bob Dylan
4. The Bells Of St. Mary's/Bing Crosby
5. Pop Star/The Pretenders
Thanks for your Tag Andrea@ My Blog?? :D/www.acthoughts.blogspot.com
I in turn, will Tag the following as to their Music Preferences for this Christmas/Holiday Season:
1. Kathy@ PurpleHaze/kathy4762.blogspot.com
2. Scott@ Scott's Web Log/sstrumello.blogspot.com
3. Megan@ This is My Life/www.thisismylife3.blogspot.com
4. Anne@ annetics/annetics.blogspot.com
5. Lyrehca@ Managing The Sweetness Within/thesweetnesswithin.blogspot.com

THE BURDEN OF DIABETES

Sometimes on a Long Cold Night, the Burden of Diabetes Becomes Heavy.

TODAY'S MENU

This evening for dinner, I prepared and had a poached chicken in a pool of noodles simmering in a turkey broth with fresh mixed vegetables.
Dessert is a yellow cake with a rich chocolate sauce that is now cooling in the refrigerator.
Ahhh................Life with Diabetes. What more can you ask for?

ANIMALS WITH DIABETES

Since all of us go through the emotional and physical upheavals daily in dealing/living with Diabetes,
do any of you have pets that have this illness as well?
If so, are you treating your dog or cat with a basal injection of insulin (Lantus or Detemir) 1X Daily?
How do you go about testing your pet's glucose level and is it done more than 1-2X Daily?
Are you then covering any Hyperglycemia with short acting insulin and if so, what are the acceptable Glucose range in
Animals?
These are some questions that I have been thinking about since dogs and cats do develop Diabetes.

THE WHOLE DIABETES PACKAGE

As those of us with Diabetes(T1DM) already know, this Chronic Illness is more than a problem of metabolism. It is a "Package Deal". For no matter how well your blood sugars are controlled and your diet is optimized, the risk of complications related to T1DM are always there. Of course, this is only my opinion but having Diabetes(T1DM) since childhood and always educating myself about this Illness, I have come to the conclusion that the potential for complications of CHD(Coronary Heart Disease), Autonomic and Peripheral Neuropathy, Kidney Disease are always present and await for the "right opportunity" to make their presence known.
Fortunately there are those within the Medical and Science Communities who have created a number of impacts to starve off a number of these horrible "Side Effects" associated with long term Diabetes. They range from the ACE Inhibitors to protect our Kidneys to the Statins offering protection related to certain aspects of CHD. There has until now, been no way of protecting the body against the damage of Peripheral Neuropathy in Diabetes until now.
Thomas Brannagan, MD and his Staff are now in Phase ll Studies to evaluate the efficiency and Safety of a Research Medication in Patients with Mild to Moderate Diabetic Polyneuropathy.
Details of this study can be found in: The Journal Of Diabetes/3/2006 called "Orally Active Neurotrophin Enhancing Agent Protects Against Dysfunction Of Peripheral Nerve in Hyperglycemic Animals".
I have met with Dr. Brannagan and found him to have the qualities that we all wish/want every Physician that we encounter to have. They are intelligence, caring, ability to communicate and optimism for what they do. These are the qualities that describe Dr. Brannagan. Corinna on Staff w/Dr. Brannigan is both intelligent and efficient. She is responsible for the Research Medications, Study Protocol, Laboratory Tests, Appointments and "just making sure that everything operates smoothly". To reach Dr. Brannagan or Corinna here in NYC and enroll or ask questions about the study you can call @212-888-8516.

TOOTH EXTRACTION

BLOOD OOZIES FROM SIDE OF MOUTH
ONTO FRESHLY LAUNDERED PILLOW CASE
AS A BROOK IN SPRING AWAKES AFTER LONG DEEP WINTER SLEEP.

PURPLE HAZE

Diabetes has its own set/time and way that it deals in destruction. It is like a truckload of Illegal Lilliputians that are not visible to you and who have a destiny to rake your Fields(Organs) for Harvest that brings forth its fruit to those in white uniforms/Lab coats as they draw your blood, inject medicines and listen to your heart.
Dedicated to: Minnesota Nice